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At beginning and end point of the study, inflammatory markers (CRP, erythrocyte sedimentation rate (ESR)), oxidative stress status (total oxidative stress (TOS), total antioxidant capacity (TAC)), and clinical variables will be evaluated also

Upon activation, microglia release pro-inflammatory cytokines, thereby directly contributing to the development and persistence of neuroinflammation [85]

In essence, selenium, through its selenoproteins and interactions with hormonal pathways, plays a pivotal role in both sperm and testosterone production