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Cytotoxicity competitive inhibitory assay The same protocol and detection method was used before (MTT) to perform them

and (3) preclinical studies demonstrating additive GH responses when GHRH and GH secretagogues are co-administered, reviewed by Muller et al

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This approach may be particularly effective in tumors with concurrent LKB1 and KEAP1 mutations that exhibit enhanced SHMT-dependent metabolism

While significant breakthroughs have been achieved in multimodal modulation of mitochondrial biogenesis, mitophagy, and dynamics, persisting challenges include incomplete elucidation of molecular regulatory networks and genetic foundations, limitations of single-pathway intervention strategies in achieving multi-target coordination, and technical barriers imposed by the selective permeability of the blood-brain barrier (BBB) that hinder clinical translation of mitochondrial-targeted therapies (Meng et al., 2024)