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10.3390/jcm6030030 25 CuiY.WengW.DingQ.SuQ.WangX

The ability to control cellular invasion and migration as well as the survival of cells has been associated with the PI3K-AKT and Ras-ERK cell proliferation pathways [141,142]

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As a naturally occurring peptide found in human plasma, GHK-Cu represents a physiological component of the body's own repair systems, which contributes to its safety - the body already has mechanisms to handle this compound, reducing the likelihood of serious adverse reactions

Abbreviations CO: Control CT: Cycle threshold CTR: Calcitonin receptor GH: Growth hormone GHR: Growth hormone receptor Hz: Heterozygous IGF-I: Insulin-like growth factor IGF-IR: IGF-I receptor IGFBP: Insulin-like growth factor binding protein KO: Knockout N.s: Not significant OC: Osteocalcin O.D: Optical density OPG: Osteoprotegerin PTH: Parathormone PTHR1: PTH receptor 1 RANKL: Receptor activator for nuclear factor B ligand RUNX2: Runt-related transcription factor 2 SEM: Standard error of mean SOST: Sclerostin