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doi: 10.1186/s12916-015-0310-y 60 GardnerABolesR
The established Observed Safe Level (OSL) for chronic, long-term supplementation is generally recognized as 2,000 mg per day, though higher doses have been used safely in monitored trials

Melnyk S, Fuchs GJ, Schulz E, Lopez M, Kahler SG, Fussell JJ, et al

Gombos G

These results align with Badawy et al
