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[33] [34] [35] The recommended dosing begins at 0.25 mg administered subcutaneously once weekly for 4 weeks, with gradual escalation every 4 weeks (to 0.5 mg, 1 mg, 1.7 mg, and maintenance at 2.4 mg) to minimize gastrointestinal side effects and improve tolerability

Bennett BJ et al (2013) Trimethylamine- N -oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation

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In FM, excess ROS formation can contribute to pain and inflammation, so the anti-oxidant properties of CoQ10 help to reduce these symptoms