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As a polar aprotic solvent which dissolves both polar and apolar compounds, with an exceptional ability to penetrate biological membranes and cellular barriers, DMSO is often exploited in research in the fields of biochemistry and cell biology 7

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formulated a nasal in situ gel containing poloxamers, hydroxypropylmethylcellulose, and borneol, which enhances geniposide permeation and adhesion at nasal temperature (Lu et al., 2011)

In a clinical study conducted by Nordio et al., the effectiveness of myo-Ins-Se, which includes myo-inositol at a dose of 600 mg/day and selenium at a dose of 83 g/day, was examined in 86 patients with Hashimotos disease and subclinical hypothyroidism over a six-month period [41]

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