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Macrophage experiments were conducted by L.B.R.S., X.Q., and B.B., and L.B.R.S

32 Cohen, Suzy, RPh

Apart from alterations in transporter expression/function, the tight-junctional barrier is impaired in ischemia-reperfusion injury, as shown in 24-or 48-h-could-stored isolated perfused rat livers subjected to reperfusion.224 Taken together, these models of long-lasting oxidative stress show consistently that cholestasis and/or impairment of the constitutive expression of transporters relevant to bile formation is a common feature in prolonged oxidative stress, and that both transcriptional and posttranscriptional mechanisms are involved

On the other hand, the use of animals in research is being discouraged worldwide, particularly when alternative methods are available, according to the 3R's principles (replacement, reduction and refinement) [83]

[DOI] [PubMed] [Google Scholar] 43.Venkataraman S., Hedrick J.L., Ong Z.Y., Yang C., Ee P.L.R., Hammond P.T., Yang Y.Y
