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Description
they recruit cAMP response element-binding protein (CREB)-binding protein (CBP) or receptor-associated coactivator 3 (RAC3), to facilitate the transactivation of NRF2 target genes [146, 147]
Furthermore, it triggers further downstream pathways, including necrosis, autophagy, transcription, and apoptosis [23,24,25,26]
Induction of Nrf2 Encoded by the Nfe2l2 gene, Nrf2 is a master regulator of multiple antioxidant enzymes such as HO-1, NQO1, CAT, SOD, glutathione peroxidase (GPx), GST, therodoxins, and glutamatecysteine ligase (GCL)
10.1371/journal.pone.0058004 54 JiangG.WangB.WangY.KongH.WangY.GaoP.et al (2023)
[DOI] [PMC free article] [PubMed] [Google Scholar] 9.Gul M., Kutay F.Z., Temocin S., Hanninen O
