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The CK activity was moderately positively associated with AST (correlation of 0.59) and LDH (correlation of 0.41), increases of which can also be associated with muscle injury (Fascetti et al 1997)

Rats given methotrexate have shown evidence of diminished nutritional status of choline and greater drug adverse reactions due to liver dysfunction (12, 124)

doi: 10.1007/s11033-021-06611-7 150 SwannK.SaundersC

This sensitivity is determined by both intercellular coupling strength and intrinsic excitability, particularly I h currents, and it is dramatically enhanced by cGMP-dependent augmentation of I h ( h currents dynamically modulate coupling coefficients in the hyperpolarized range, shortening the coincidence detection window and suggesting that electrical synchrony and sensory processing in Vmes circuits are dynamically regulated (Trigo et al., 2025)