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Colchicine is not safe in patients with substantial kidney or liver disease and should not be used along with drugs such as ketoconazole (eg, Nozoral), fluconazole (Diflucan), clarithromycin (Biaxin, an antibiotic), cyclosporine (eg, Sandimmune, an immunosuppressant agent), or ritonavir (Norvir, an antiviral drug) due to the potential for drug-drug interactions

fixed heart rate (cardiovascular autonomic neuropathy) Entrapment / Mononeuropathy-Specific Carpal tunnel: nocturnal hand paresthesias, thenar atrophy, positive Tinel/Phalen signs Ulnar neuropathy: ring/little finger numbness, intrinsic weakness, claw hand Peroneal neuropathy: foot drop, steppage gait Sciatic neuropathy: posterior thigh/leg pain, weakness of knee flexion and all distal muscles Meralgia paresthetica: anterolateral thigh burning/numbness, no motor deficit CDI Query Trigger When documentation records peripheral neuropathy in a patient with Type 2 diabetes mellitus, query for diabetic etiology linkage

The published literature on each compound is included here for educational context only

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Local plus systemic coverage: BPC-157's tendency toward local action combines with TB-500's systemic distribution to address injuries at multiple scales simultaneously