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In SELECT, investigators were allowed to slow, decrease or pause treatment

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Clinical trials demonstrate average weight loss of 10 to 15% of total body weight over 68 weeks at the 2.4 mg weekly dose

Methionine S-adenosyl methionine (SAM), a methionine metabolite, may interact with opioids, antipsychotics, amphetamines, and antidepressants to cause an overabundance of serotonin to accumulate in the body
