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Interestingly, works done by Wu et al

Possible causes include the following: (1) The calcification of bacteria in plaque with phosphorus and calcium in saliva (2) Using a toothpaste that does not contain a preparation that penetrates and sterilizes the bacteria that causes calculus in plaque

Safaiyan et al., 2016

The GSH:GSSG ratio reflects cellular redox balance healthy cells maintain ratios above 100:1, meaning reduced glutathione vastly outnumbers oxidized glutathione

During M2 macrophage polarization, the IL-4/STAT6 signaling pathway upregulates YY1, leading to the formation of a liquid-liquid phase separation (LLPS) structure