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doi: 10.1155/2020/5021983 193 SoundararajanPKimJS

600 Despite the large number of studies on its potential, translating these effects into robust clinical outcomes has proven challenging

Therapeutic opportunities Ferroptosis inducers Many ferroptosis inducers and ferroptosis-related genes and pathways have been discovered [7] (Table 1)

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The alignment highlights that class III GRXs do not encode the class II-specific five amino acid loop which interferes with oxidoreductase activity 14,15 , nor the proline in the active site which might interfere with FeS cluster assembly 16