mdma and glutathione Induction of synthesis conjugation by 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-dihydroxymethamphetamine (HHMA) in human and rat liver cells, including the protective role of some antioxidants Human Pharmacology of MDMA :
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JIMD Rep 13:2731

Additionally, ERGO was able to attenuate oxidative stress by reducing MDA content and enhancing T-SOD activity via the Nrf2/HO-1 pathway, further supporting its neuroprotective effects [72]
B., Fried, V

That's because glutathione depletion is not only common, it can be a normal part of aging
