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National Library of Medicine, National Institutes of Health, dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8daa5562-824e-476c-9652-26ceef3d4b0e

We also employed a Phlh-11::GFP transcriptional fusion strain to test whether transcription of hlh-11 is also regulated by nutrient conditions

The potential molecular mechanisms underlying these effects included disturbances in redox homeostasis (as evidence by the enhanced production of ROS and reactive nitrogen species), failure of enzymatic and nonenzymatic cytoprotective mechanisms involving the glutathione system as well as nuclear factor kappa B (NF-B) and fibroblast growth factor 2-mediated pathways, and impaired mitochondrial function

Early diagnosis and treatment are key to preventing complications