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2.2.1.3 Mechanism of SLC7A11 and p53 in the regulation of ferroptosis Suppression of SLC7A11, a key component of system Xc , induces intracellular GSH depletion, subsequently initiating ferroptosis (Guo et al., 2022

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In the presence of hydrogen peroxide, they are converted to agents with increased chelation ability (e.g., hydroxylation of the aromatic ring), which may thus chelate iron more readily