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These results suggest that, under cysteine-limiting conditions, the recovery of the mitochondrial cysteine pool is prioritized over the cytosolic pool

From a clinical perspective, it suggests that in disease states with high IL-5 (like hypereosinophilic syndromes or active IBD with a type 2 skew), targeting Siglec-8 could be especially effective in depleting pathogenic eosinophils

Dual PI3K/mTOR inhibitor PKI-402 suppresses the growth of ovarian cancer cells by degradation of Mcl-1 through autophagy

Biomedicines 10(3):524 Gedgaudas R, Bajaj JS, Skieceviciene J, Varkalaite G, Jurkeviciute G, Gelman S et al (2022) Circulating microbiome in patients with portal hypertension