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Description
Tesofensine is a triple monoamine reuptake inhibitor that increases thermogenesis and energy expenditure by 1015%, producing weight loss through elevated metabolic rate
a Pilot Study
The mechanisms underlying this effect may involve the modulation of urate transporters, inhibition of XO activity sites, suppression of the TLR4/NF-B signaling pathway, and modulation of the NLRP3 signaling pathway (98, 99)
Therefore, activation of Piezo1 channels may reduce the transition of astrocytes from an anti-inflammatory state to a proinflammatory state, thereby suppressing inflammation
Orozco, J
