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Evidence-Based Interventions for Reducing Sickle Cell Disease-Associated Morbidity and Mortality in Sub-Saharan Africa: A Scoping Review

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A synergistic effect was observed as most interventions provided some positive effects, but the most profound increase in electroencephalogram (EEG) resting state theta activity (indicative of a relaxed and alert state) was observed in the group where all the nutrients were provided in one treatment (Rhodiola + green tea + Mg + B vitamins)

Additionally, ROSinduced ribosomal oxidation activates the ZAK pathway and inhibits mitochondrial biogenesis and mitochondrial autophagy, thereby exacerbating ROS leakage and accelerating the dysfunction of adipose tissue [121]