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It typically resolves within days

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

Secondly, B12 shots dont always resolve the underlying problem of deficiency, so theyre not the be-all and end-all when it comes to treating symptoms

Regulation and roles for claudin-family tight junction proteins

Duration of treatment depends on the underlying cause: Lifelong therapy is required for pernicious anaemia or irreversible malabsorption (e.g., after gastrectomy) For dietary deficiency without malabsorption, treatment may be reviewed once deficiency is corrected and neurological symptoms have resolved Oral B12 supplementation is generally not recommended for patients with neurological symptoms, particularly when pernicious anaemia is the cause
