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The metal-peptide complex can dissociate at elevated temperatures, releasing free copper and reducing efficacy
6 Future perspective and conclusion Preeclampsia is a disease that specifically occurs during pregnancy
In SURMOUNT-1, adults with obesity or overweight without diabetes were randomized to tirzepatide or placebo for 72 weeks
In mice and rats, tirzepatide caused a dose-dependent and treatment-duration-dependent increase in the incidence of thyroid C-cell tumors (adenomas and carcinomas) after lifetime exposure at clinically relevant plasma exposures
But it barely outperformed an existing drug
