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The EOAD begins at early age, less than 65 years, and only explains 5% of all cases

In the adult mouse brain, scRNA-seq studies showed that IDH2 was most highly expressed in ependymal cells, astrocytes, and microglia, with lower expression in oligodendrocytes and much lower expression in neurons (Saunders et al., 2018)

This modified LDL exhibits enhanced uptake by vascular endothelial cells and macrophages, driving oxidative stress and accelerating atherosclerosis progression[68]

The risk controls also define the role of the private debt in complementing the fixed income portfolio diversification in the long run

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