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Abstract Neuropathic pain, a disease of the somatosensory nervous system, afflicts many individuals and adequate management with current pharmacotherapies remains elusive

In particular, the DNA methylation status of the analyzed loci showed significant differences between high-risk and low-risk patients, with higher methylation levels observed in high-risk patients

doi:10.3390/cells8020184 Mandala S, Hajdu R, Bergstrom J, Quackenbush E, Xie J, Milligan J, Thornton R, Shei GJ, Card D, Keohane C, Rosenbach M, Hale J, Lynch CL, Rupprecht K, Parsons W, Rosen H (2002) Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists

While the science is promising, its important to know that most detailed studies so far have been in animals