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The published data show that estrogen-like molecules can mimic or block endogenous estrogens biological effects through a series of non-genomic responses (Park et al., 2012

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Along this line, ipRGCs projecting to thalamic, hypothalamic and midbrain nuclei contain glutamate and pituitary adenylate cyclase-activating polypeptide (PACAP) as neurotransmitters (7679), two molecules that have been largely implicated in migraine pathophysiology