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Um den Organismus vor unkontrollierten, oxidativen Prozessen zu schtzen, haben sich effiziente, sogenannte antioxidative Mechanismen etabliert

demonstrated that the E3 ubiquitin-protein ligase TRIM3 functions as a tumor suppressor by degrading SLC7A11, thereby inhibiting the tumorigenesis of non-small cell lung cancer (NSCLC) [24]

doi: 10.1016/j.pmpp.2015.10.001 137 SinghM.AvtarR.LakraN.PalA.SinghV

In context of this review, it is interesting to note that studies have shown that silencing the GSTA4 (GST alpha) gene results in mitochondrial dysfunction, as is also seen in GSTA4 null mice, which could contribute to insulin resistance in type 2 diabetes [97]

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