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The ATG4 protease integrates redox and stress signals to regulate autophagy
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These processes are closely linked, as aging leads to an accumulation of cellular senescence
doi:10.1016/j.freeradbiomed.2012.02.026, PMID: 22387197 Martn SF, Sawai H, Villalba JM, Hannun YA (2007) Redox regulation of neutral sphingomyelinase-1 activity in HEK293 cells through a GSH-dependent mechanism
New drug therapies have begun to focus on combination therapy using medications that target more than one of these central pathways, thereby achieving more favorable weight loss outcomes
