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Helicobacter pylori promotes apoptosis, activates cyclooxygenase (COX)-2 and inhibits heat shock protein HSP70 in gastric cancer epithelial cells
For instance, one analysis of 350 patients demonstrated that the omission of adjuvant radiotherapy was associated with a significantly elevated 5-year risk of local failure (risk ratio 4.50)
These observations imply that MurJ has a higher affinity for lipid II, its natural substrate, than either MurG or MraY
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