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Additionally, erythrocytes can scavenge chemokines via Duffy antigen receptor for chemokines (DARC), leading to changes in their availability and consequent regulation of immune cell migration [57]

One type of messenger which has received significant attention recently are small molecule oxidative or free radical agents, which include reactive oxygen species (ROS)

El-Gedaily A, Paesold G, Chen CY, Guiney DG, Krause M (1997) Plasmid virulence gene expression induced by short-chain fatty acids in Salmonella dublin : identification of rpoS-dependent and rpo-S-independent mechanisms

Chronic lack of sleep has been shown to deplete glutathione levels

The clinical significance arises when B12 is elevated without a clear exogenous explanation