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Such a mechanism implies that S10 phosphorylation is transient and conditional, which provides a straightforward explanation for why the non-phosphorylatable S10A mutant often phenocopies WT: under basal conditions, GABARAPL2 is expected to be largely unphosphorylated, and thus WT and S10A behave similarly

Through the RNA sequencing analysis of mice exposed to narrow band noise and treated with MSCs, the marked upregulation of genes related to immune modulation, hypoxia response and mitochondrial function was observed, alongside the downregulation of genes associated with synaptic remodeling and calcium homeostasis

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In addition, the investigators observed increased expression of a gene called c-myc and increased accumulation of breaks in the DNA strand, both of which predispose to hepatocellular carcinoma (HCC)