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Conversely, other studies reported no significant differences in GPX3 serum concentrations between obese and lean individuals, although GPX3 expression in subcutaneous adipose tissue increased after weight loss and was greater in lean and insulin-sensitive individuals than in their obese and insulin-resistant counterparts [139]

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Diagnosis is made with a battery of visual tests including perimetry, gonioscopy, intraocular pressure testing, optical coherence tomography for evaluation of the retinal nerve fiber layer and ganglion cell thickness, and pachymetry [120]