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Notably, NHP models vaccinated with mRNA-1083 showed high neutralizing antibody titres against the Omicron variant and diverse influenza strains, along with significant T-cell responses that contributed to broader immunity 52

Additionally, SIN exhibits antidepressant effects, significantly reversing the decrease of NE and serotonin levels in the hippocampus of mice subjected to chronic unpredictable mild stress, with improvements in depression-related symptoms (134)

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Inhibition of notch activity promotes nonmitotic regeneration of hair cells in the adult mouse utricles