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First isolated from human plasma in the early 1970s, it naturally occurs in blood, saliva, and urine but its concentrations decline sharply with age

10.1016/j.ijwd.2020.09.006 Handog EB, Datuin MS, Singzon IA: An open-label, single-arm trial of the safety and efficacy of a novel preparation of glutathione as a skin-lightening agent in Filipino women