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Importantly, the surface charge of metallic NPs plays a cardinal role in their stability (eg, tendency to aggregate) in aqueous solution and in the body [41]
Recent evidence has shown that in addition to trophoblasts, leptin induces HLA-G expression on myocytes and inhibits contraction and differentiation of these cells
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The same approach is being applied to AxD patients in an ongoing phase 13 clinical study (Zilganersen, NCT04849741
It is easy to administer and can be stored for a long period, especially if it is refrigerated
