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The results of this paper showed that mitochondrial dysfunction associated with cell apoptosis including membrane potential loss, down-regulation of Bcl-2 and up-regulation of Bax, activation of caspase-3, and the release of cytochrome c were abrogated in the presence of L-carnitine [52]

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8 Cavallini G, Ferraretti AP, Gianaroli L, Biagiotti G & Vitali G
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If a patient requires smaller dose adjustments than that available with Depakote ER, Depakote should be used instead
