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doi: 10.1016/j.mad.2016.01.002 Nita M., Grzybowski A

Unlike many large molecules, SAMe effectively crosses the blood-brain barrier, allowing it to directly influence neurological health

[Crossref] Costa LG, Garrick JM, Roqu PJ, Pellacani C (2016) Mechanisms of neuroprotection by quercetin: counteracting oxidative stress and more

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Protocol 4: nasal spray approach Goal: Needle-free administration with acceptable bioavailability trade-off Duration: 20 days active, then 4-6 months off Schedule: Days 1-20: 10-15 mg epitalon intranasally, divided into 2-3 daily doses Days 21-180: Off cycle Repeat 1-2 times per year Formulation: Reconstitute in saline with 3 percent DMSO for improved nasal absorption