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When cells are exposed to toxicants, either these nodes may change (altered metabolite concentration) or remain relatively constant, or the connections originating from them may change (altered metabolic flux)

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12 Therefore, since folate status modulates both genetic stability and DNA methylation, these critical indices are determined by both dietary intake and the activity of a number of folate metabolism enzymes, many of which exist in polymorphic form

[DOI] [PubMed] [Google Scholar] 85.Watanabe M., Osada J., Aratani Y., Kluckman K., Reddick R., Malinow M.R., Maeda N