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A cell that is activating MOTS-c-mediated metabolic improvement but is depleted of NAD+ is like an engine receiving a better fuel signal but running low on fuel itself

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Furthermore, processes required for wound healing and extracellular matrix remodeling are dramatically reduced when fibroblasts and macrophages are rendered TGM2 deficient by transfection with antisense RNA (Stephens et al., 2004

Whether that separation is always accurate depends on the study or model being referenced, which is one reason its useful to understand what each peptide is (and isnt) known for