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Subgroup analysis showed an ORR of 20% and a median progression-free survival (PFS) of 3.9 months in melanoma patients with positive intratumoral RIPK3 expression (IHC score 2+), while no objective responses were observed in RIPK3-negative patients, validating RIPK3 as a predictive biomarker for necroptosis-targeted therapy

[PMC free article] [PubMed] [Google Scholar] Use of an overhead goal alters vertical jump performance and biomechanics

Macrophages can be classified based on location, origin, and immune phenotypes, including alveolar macrophages (AMs) and interstitial macrophages (IMs), monocyte-derived inflammatory macrophages (MDMs) and tissue-resident macrophages 24,25

Like Tel1, Mec1 phosphorylates histone H2A on serine 129, allowing Rad9 recruitment and full activation of Rad53 effector kinase