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To ensure the adaptive metabolic responses of cells in hypoxia, this mechanism required the HIF-1-dependent expression of BNIP3 and constitutive expression of Beclin-1 and Atg5, which lowered mitochondrial numbers and prevented a increase in ROS [29]

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Nerolidol Nerolidol is a sesquiterpene compound having promising antioxidant and anti-inflammatory properties [85, 86]

Inhibition of Nrf2 expression or activity can increase the sensitivity of tumors to anticancer drugs [87]