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Description
The suppression of the NF-B activity by curcumin is associated with the downregulation of AP-1 families of transcription factors [185]
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PMID 11325542
The early cancer therapies referred to antimetabolites, such as methotrexate (a folate analog) and 5-FU (a pyrimidine analog), that competitively inhibit key metabolic enzymes (e.g., dihydrofolate reductase and thymidylate synthase) in in vivo , thereby affecting or antagonizing cancer cell metabolism and proliferation (Lukey et al., 2017
