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Mechanism of action of pentagastrin and acetylcholine on the longitudinal muscle of the canine antrum

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SARS-CoV-2, the virus responsible for the 2020 COVID-19 pandemic (103), belongs to the genus Betacoronavirus and subgenus Sarbecovirus and, due to its similar receptor-binding domain, it is assumed, similarly to SARS-CoV, to infect type II pneumocytes entering via the angiotensin-converting enzyme II receptor (104)

Cleavage sites resulting from oxidative damage occur preferentially between the residues phenylalanine, cysteine, glycine, leucine, valine, and tyrosine (100), as well as near the cysteine bridges, especially in chain A (99)

A mechanistic study indicated that the combined administration of TSA and As-IV exerted anti-apoptotic, antioxidant and anti-inflammatory effects in MIRI by synergistically inhibiting the STING pathway, with superior efficacy compared with monotherapy (127)