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This has led to the discovery of a range of chemical compounds suitable for further study in clinical trials

Activated IGF-1R can activate phosphatidylinositol-3 kinase (PI3K)/serine-threonine kinase (Akt)/mammalian target of rapamycin (mTOR) and Ras/Raf/mitogen-activated protein kinase (MAPK) signaling to achieve cell survival and proliferation [13]
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Surfacemodified nanoparticles with targeting ligands such as peptides, antibodies, small molecules, and aptamers are tailored to actively recognize the pathological cells with unique receptors or biomarker proteins (Table 2) in lung diseases

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