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It uses the Bemis-Murcko scaffolds to group molecules, and then puts the smallest groups in the test set
Zone 1 comprises only 6.62% of the journals (N = 45) but contributes to a disproportionately large share of the literature which aligns with Bradfords law, which states that a small core of journals often produces most of the relevant research in any given domain (Brookes 1969)
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Pellegrini A, Kalkinc M, Hermann M, Grnig B, Winder C, von Fellenberg R: Equinins in equine neutrophils: quantification in tracheobronchial secretions as an aid in the diagnosis of chronic pulmonary disease