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Tri-stimuli-responsive biodegradable theranostics for mild hyperthermia enhanced chemotherapy
L.RehmanM.WaltherT
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2014;164A(2): 421424
Some scholars have discovered by knocking out the mouse SQSMT1 gene that SQSTM1 mediates ULK1 phosphorylation to activate autophagy and promote the formation of AMPK-ULK1-SQSTM1 complex, which leads to autophagic Keap1 degradation and activates the non-canonical Keap1-Nrf2 pathway, thereby protecting mouse liver from lipotoxicity (Figure 4) (Lee et al., 2020)
