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Currently there is a clinical trial using YIV906 in patients with hepatocellular cancer being treated with sorafenib [24]

& Hultberg, M

doi: 10.1016/j.ijbiomac.2019.05.072, PMID: [DOI] [PubMed] [Google Scholar] 35.Pateiro M, Gmez B, Munekata PE, Barba FJ, Putnik P, Kovaevi DB, et al

However, given that previous demonstrations of longevity resulting from disruption of this pathway occurred either at conception or in young adulthood 6,7,17,18,19 , along with the reported importance of low exposure to GH (and IGF-1) signals early in life on longevity and related outcomes 20,21 , whether benefits can be achieved by targeting this pathway later in life is unclear

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