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Notably, although both CCKRs adopt the canonical seven-transmembrane architecture, they differ from other reported class-A GPCRs with a shortened TM4 helix, which is attributed to the unwinding of the helix at the extracellular half caused by the presence of P 4.59 and the additional P 4.61 (the superscripts refer to the BallesterosWeinstein number) 44

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In rare cases, some people might have severe side effects like: Skin rash, itching, or hives Swelling of the face, lips, or tongue Chest pain or tightness Blue tint to the skin Difficulty breathing or wheezing A swollen, painful area on the leg Dizziness If you experience any of the above side effects, reach out to a healthcare provider immediately