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Selected Preclinical Findings NNMT knockdown protects against DIO via increased energy expenditure and remodeled polyamine flux

These medications are transforming the treatment landscape, dramatically improving the amount of weight loss achievable through medication alone or in combination with lifestyle interventions, shared Miranda Stiewig-Rapp, assistant professor of endocrinology at UC Davis Health

The goal is to prevent irreversible nerve damage

That doesnt make these compounds useless for research the safety profile is well-established, the mechanism is plausible, and moderate fat loss with no hormonal disruption is a meaningful profile for the right researcher