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These include nausea and vomiting [63], respiratory depression [64], and subsequently tolerance and dependence [65]

Effect of oxidative stress on translocation of DAF-16 in oxygen-sensitive mutations, mev-1 and gas-1 of Caenorhabditis elegans

A summary of redox changes occurring in the blood and different tissues with aging, fasting, and DR is shown in Table 1

Even in picogram quantities, they can elicit strong inflammatory and cytotoxic responses in mammalian cells, confounding experimental results

Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1
