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As depression has been previously shown to be associated with changes in neurometabolites, mood and anxiety ratings were performed: the Beck Depression Inventory II (BDI-II) [30] for mood, the Spielberger State Anxiety Inventory (STAI) for anxiety [31]

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Furthermore, resources of the affected zones are often scarce, particularly in remote areas where the disease is mostly found, urgently calling for safer and easier therapies (Figure 1)

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