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[DOI] [PMC free article] [PubMed] [Google Scholar] 30.Keller J, Ringseis R, Priebe S, Guthke R, Kluge H, Eder K

290292 Accumulating macrophages release cytokines and chemokines, including IL-1, IL-6, chemokine ligand 2 (CCL2), and TNF-, intensifying the inflammatory environment and aggravating nerve damage

All tests were two-sided and P 0.05 was considered statistically significant

Instead, it is more appropriate to envision metabolic plasticity regarding uptake of alternative metabolic substrates and promotion of metabolic rewiring as a built-in feature that has evolved to allow cancer cells to constantly adapt to changing intracellular- and extracellular metabolic conditions 2

The role of cytokines in cancer cachexia